papaya, Carica papaya

When my mom hit menopause, she was faced with an important decision: hormone supplements or potentially “suffering and living with it.” Her doctor recommended hormonal replacement therapy (HRT) with medications containing progesterone and oestrogen. And initially, with her first prescription, she did get on it. But while she was on HRT, she said that she never felt quite right.

And then there was all this research about long-term HRT increasing the likelihood of breast cancer. So she stopped taking her supplements and started experiencing the symptoms of menopause: sleep difficulties, night sweats, hot flashes, and general irritability.

Soon, however, she read about the power of the papaya fruit for menopausal women. She had heard about soy, but she never thought she’d drink enough soymilk or eat enough soy products to counter the symptoms. With papaya, however, she felt that she had a natural, nutritional supplement that could offer her a third alternative to dealing with menopause.

Even within a week of eating freshly cut papayas or adding them in homemade smoothies, she felt healthier and less irritable. She soon stopped experiencing menopausal symptoms completely. To this day, she continues to eat papayas once a week or at least every other week, and even more often, when they are in season.

Papaya is such a delicious fruit overall, so I encourage you to try some today. The health benefits are enormous (scroll down to “Who’s done the research” to read more.).

WARNING: Pregnant women should not eat papaya. It is not just “a folk remedy for contraception and abortion.” Research on pregnant mice (see last research bullet) has shown that papaya, especially in its unripened form, does affect the foetus. However, fully ripe papaya is not considered dangerous.

How to cook/eat papaya: Although I’ve never eaten cooked papaya before, is used to tenderize meat. As mentioned above, my mother and I like to eat ripe and freshly cut papaya by itself or blended in a smoothie. For some reason, papayas go great in smoothies. Maybe it’s because they are mushy, like bananas. When the papaya is just ripe, it is quite sweet, especially towards the bottom of the fruit.

Where to find it: You can find fresh papayas at your local grocery store. Choosing the right papaya is the fun part. My mother and I prefer Mexican papayas over Hawaiian papayas. The former is more elongated, while the latter is more round. To pick a good Mexican papaya, look for the lengthier one; they usually have more meat to them, whereas the rounder Mexican papayas have more empty space inside and more seeds.

When choosing papayas, it’s good to know when you want to eat them. If you want to eat right away, pick a papaya with golden colors and soft to the touch, but not bruised nor shriveled, of course. If you wish to eat it later in the week, pick one that is more intermediate in color, between green and golden. When you bring it home, don’t store it in the refrigerator. Allow it to complete it’s golden color and soften; then you’ll know when it’s ready to eat.

What else: So what makes the papaya a great solution to cure your menopausal blues? It’s the phytoestrogen! Read on, to learn more about this funky hormone…

Who’s done the research:

    • Papaya, for example, contains phytoestrogen, which can be added to your diet to help increase estrogen in your body…Phytoestrogens are similar but not identical to the estrogen produced by the body. Phytoestrogens are plant-derived compounds, and are more natural than the prescribed drugs on the market. – Senzon, Sandra & E. Chronimed Zack. Reversing Gum Disease Naturally: A Holistic Home Care Program. 2003:29-30.

    • In various societies, older women traditionally eat certain foods to remedy menopausal side effects. In the South Seas, for example, women of menopausal age eat papaya, which contains phytoestrogens, once a day. Studies are beginning to show that these plant compounds can be helpful in menopause. Traditional diets in Japan also are rich in phytoestrogens. Studies of Japanese women with traditional Japanese diets show that these women’s bodies contain levels of plant estrogens up to 1,000 times the level found in Western women, according to Dr. [Fredi] Kronenberg. “It may be that the reason these women don’t have hot flashes is that they are eating a lot of weakly estrogenic substances all the time. These women also have a lower incidence of breast cancer, and one of the reasons suggested for this is that there are other things in the plant foods that are anticarcinogenic.” In these studies, the higher estrogen levels were associated with intake of soybeans, soy products such as tofu and miso, and boiled beans.” “As much as 50% of the Japanese diet contains phytoestrogenic foods, whereas Westerners eat 10% or less,” Dr. [Susan] Lark points out. “We really have very little dietary support as far as suppression of hot flashes and other menopausal symptoms.” – Goldberg, Burton, et al. Alternative medicine: the definitive guide. 2002: 962-63.

    • Traditional western medicine often limits women with menopausal symptoms to two choices; (1) hormonal replacement therapy (HRT) with medications containing progesterone and oestrogen, or; (2) suffer in silence and “live with it”. Dietary modifications and nutritional supplements offer a third alternative. A number of foods and herbs are sources of natural plant oestrogens. These herbs and foods are known as Phytoestrogens and can be very helpful in the treatment of menopausal symptoms. Foods containing natural oestrogens include alfalfa, almonds, anise seed, apples, barley beets, cabbage, carrots, chickpeas, clover, corn, cucumbers, fennel, flaxseeds, garlic, green beans, green squash, hops, liquorice, oats, papaya, parsley, peas, plums, potatoes, pumpkin, red beans, red clover, rhubarb, rice, rye, sage, sesame seeds, soybean, soy bean sprouts, split peas, squash, sunflower seeds, walnuts, wheat and yams. A medical review of over 600 studies concluded that phytoestrogens exhibit physiological changes in humans and oestrogenic changes in postmenopausal women. The data was so encouraging that the authors suggested further research be conducted to assess the role of phytoestrogens in cancer prevention. – Murkies AL, Wilcox G, Davis SR. Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab. 1998 Feb; 83(2):297-30.

    • Carica papaya promotes significant wound healing in diabetic rats and further evaluation of this activity in humans is suggested. – Nayak SB, et al. Wound healing activity of Carica papaya L. in experimentally induced diabetic rats. Indian J Exp Biol 45(8):739-43, Aug 2007.

    • Carica papaya has antibacterial effects that could be useful in treating chronic skin ulcers to promote healing. – Dawkins G, et al. Antibacterial effects of Carica papaya fruit on common wound organisms. West Indian Med J 52(4):290-2, Dec 2003.

    • The effect of vegetable and fruit consumption on breast cancer risk is controversial. We examined the association between vegetable and fruit intake and breast cancer risk in a hospital-based case-control study conducted in Guangdong, China. Four hundred and thirty-eight cases were frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). Dietary intake was assessed by face-to-face interviews using a validated food frequency questionnaire. Consumption of individual vegetable and fruit groups such as dark green leafy vegetables, cruciferous vegetables, carrots and tomatoes, banana, watermelon/papaya/cantaloupe were all inversely and significantly related with breast cancer risk. An inverse association was also observed for vitamin A, carotene, vitamin C, vitamin E, and fiber intake. These data indicate that greater intake of vegetables and fruits is associated with a decreased risk of breast cancer among Chinese women residing in Guangdong. – Zhang CX, Ho SC, Chen YM, Fu JH, Cheng SZ, Lin FY. Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women. Int J Cancer. 2009 Jul 1; 125(1):181-8.

    • This study reports an ethnobotanical survey by means of semi-structured questionnaire of medicinal plants in five districts of Lagos State of Nigeria reputed for the treatment of diabetes. 100 respondents from the predominantly Yoruba tribe mostly males (76%) were knowledgeable in traditional treatment of diabetes. About half of the respondents with 20-30 years experience in treating diabetes used mainly herbs (96%) and have developed effective and easily recognised diagnostic tools. 92% of diabetic patients were usually out-patients aged 21-60 years. Diabetes trado-specialists (80%) rarely referred their patients but usually treated referred cases (96%). Fifty multi-component herbal recipes covered in the survey were mainly liquid preparations often administered without serious side effects (92%). The principal antidiabetic plants included Vernonia amygdalina, Bidens pilosa, Carica papaya, Citrus aurantiifolia, Ocimum gratissimum, Momordica charantia and Morinda lucida. Dietary recommendations also accompanied therapy. – Gbolade AA. Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria. J Ethnopharmacol. 2009 Jan 12; 121(1):135-9.

    • Many aspects of the pathology in beta-hemoglobinopathies (beta-thalassemia and sickle cell anemia) are mediated by oxidative stress. Fermented papaya preparation (FPP) was tested for its antioxidant effects. Results suggest that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia. – Amer J, Goldfarb A, Rachmilewitz EA, Fibach E.
    Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients. Phytother Res. 2008 Jun; 22(6):820-8.

    • The traditional use of papaya to treat many diseases, especially skin conditions and its prohibition for consumption during pregnancy has prompted us to determine whether papaya extracts both from green and ripe fruits improve wound healing and also produce foetal toxicity. Aqueous extracts of green papaya epicarp (GPE) and ripe papaya epicarp (RPE) were applied on induced wounds on mice. GPE treatment induced complete healing in shorter periods (13 days) than that required while using RPE (17 days), sterile water (18 days) and Solcoseryl ointment (21 days). Extracts were to pregnant mice from day 10 and onwards after conception. 3 mice and 1 mice given RPE and misoprostol, an abortive drug, respectively experienced embryonic resorption while this effect was observed in none of the mice given GPE and water. The average body weight of live pups delivered by mice given GPE was significantly lower than those delivered by mice given water. In SDS-PAGE, proteins were distributed in three bands (Mr range approximately 8-29 kDa). Band intensity at Mr approximately 28-29 kDa was higher in GPE than in RPE. In contrast, band intensity at low Mr (approximately 8 kDa) was found to be higher in RPE than in GPE. Notably, the band corresponding to Mr approximately 23-25 kDa was absent in RPE. These differences in composition may have contributed to the different wound healing and abortive effects of green and ripe papaya. – Anuar NS, Zahari SS, Taib IA, Rahman MT. Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy. Food Chem Toxicol. 2008 Jul; 46(7):2384-9.

egg white

Venturing into non-dietary territory, for the last three weeks, I’ve been trying out the egg white facial mask. Like with many other treatments, both dietary and other, I started out by doing it once a day, towards the evening, before bed. Cracking a raw egg and separating the egg white into a container, I apply the egg white onto a cleansed face. As soon as the egg white dries and my face feels like it’s starting to freeze, I rinse it off with a wet towel. In my opinion, there was an immediate difference in the tightening of the pores by morning. After a full week of this, I started applying the egg white facial mask every other day, and now every two days.

The most amazing thing the egg white facial does is treat rising acne. As you may have read from the pearl barley post, I’ve tried other topical treatments before, and I’ve noticed that all of them “treat” acne by speeding up the healing process. However, I have to say, early in the first week, I felt a pimple rising irritatingly (still unseen, but felt) on my chin, and after I applied the facial mask in the evening, I arose in the morning with the hint of the pimple completely gone.

There were no bumps and no feeling what-so-ever of anything rising from underneath the skin. That’s when I truly believed the cleansing power from the simple egg white.

Try it yourself today. What have you got to lose?

pine nut, Pinus pinea

20090525pinenut While we’re in the subject of nuts – or seeds conveniently called nuts – one of my favorites has got to be the pine nut. In salads, with steamed tilapia, in moon cakes, or just by itself, pine nuts lend a special flavor that is incomparable to other nuts, in my opinion. What’s more: it is packed with nutrients, like vitamins A (sharpens vision; boosts immunity), C (boost immune system; combats cardiovascular disease), D (stronger bones and teeth), E (antioxidant), K (promotes proper blood clotting; promotes against osteoporosis), magnesium, potassium, and an excellent source of fiber. They are also high in monounsaturated fats to help reduce blood cholesterol and antioxidants to protect the body’s cells.

While we understand that most nuts have healthy oils and nutrients, what makes the pine nut stand apart from the rest? Well, recent studies have shown that pine nuts can curb your appetite (scroll down below to read the research). In addition, my family have found it a good remedy for cracked heels and calluses from those long summers of flip flops and sandals.

Beauty care professionals have come up with a variety of solutions for dry and rough feet, from soaking in various liquid substances; mixing a pumice stone with a callus shaver; and/or applying Vaseline and sleeping with socks. But ever try adding a little something to your diet?

Not too long ago, my dad – an all-year-round sandal-wearer – started incorporating pine nuts into his diet on a regular basis. Soon after that, he noticed that his feet (and heels) had naturally become smoother, less dry and rough from all that exposure in the elements. My mom tried it, with similar results. As Spring approaches again, our feet are all ready for Summer!

How to cook pine nuts: Like with other nuts, a quick Internet search will retrieve countless recipes using pine nuts. I usually buy some raw pine nuts, toast them lightly, and keep a stash handy in my bag.

Where to find it: Like almonds, pine nuts can be found in most grocery stores, both in the raw and toasted variety. While in the nuts section, be sure to try some of your other healthy “nutty” selections.

What else: For those who are allergic to nuts, be careful! Individuals who are allergic to one tree nut may not be allergic to another; and although allergies to pine nuts are less common then, say, to peanuts or walnuts, it is always smarter to exercise precaution.

Who’s done the research:

    • Pine nut FFA and pine nut TG supplementation seem to increase the satiety-inducing hormones CCK and GLP-1 concentrations postprandially. This may lead to a reduced prospective food intake suggesting that pine nut FFA and TG may act as an appetite suppressant in overweight women. Further human studies are needed to confirm these effects and to evaluate effects on actual food intake and body weight. – Pasman, Wilrike J, et al. 2008 The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women. Lipids in Health and Disease, 7(10).
    • Pine nuts are high in nutritional value. For instance, Stone pine (Pinus pineal) seeds have a protein content up to 31.6% of the total dry weight of the edible portion. They also contain a considerable amount of vitamins A, B1, and B2, potassium, magnesium, and other minerals as well as dietary fiber. – Jin, Tengchuan, et al. 2008. Purification and Characterization of the 7S Vicilin from Korean Pine (Pinus koraiensis). J. Agric. Food Chem. 56(17): 8159-65.
    • Similar to other tree nuts and peanut, pine nut is also known to be a source of food allergins. – Jin, Tengchuan, et al. 2008. Purification and Characterization of the 7S Vicilin from Korean Pine (Pinus koraiensis). J. Agric. Food Chem. 56(17): 8159-65.
    • Pine-nut oil (PNO, Pinus sibirica), which is widely used in medicine to treat burns, boils, eczema, psoriasis, stomach ulcers, and other diseases, is the most well-known. – A. Ivanova. 1997. Treatment With Pines and Other Conifers [in Russian], OOO Averseb, Minsk. 207.
    • Pine-nut oil can normalize the blood lipid spectrum; has cholesterol-lowering activity; assists the reduction of surplus body mass and, as a result, corrects these risk factors; lowers arterial pressure, etc. – E.E. Zhukova, et al. 2005. Masla Zhiry 2(9).
    • [Pine nuts] have important health properties associated with reduction of the risk both of coronary heart disease and non-fatal myocardial infarction. – Nergiz C, Conmez I. 2004. Food Chem 86:365.
    • The pine nut oil is known as the only conifer nut oil rich in pinolenic acid (5,9,12-18:3)…Many studies have shown that pine nut oil has hypocholesterolemic activity in animals. For example, it reduces blood pressure and attenuates serum VLDL-TAG and VLDL cholesterol. – Lee, Jin-Won, et al. 2004. Selective Increase in Pinolenic Acid (all-cis-5,9,12-18:3) in Korean Pine Nut Oil by Crystallization and Its Effect on LDL-Receptor Activity. Lipids 39: 383-87.

Job’s tears, Chinese pearl barley, Coix lacryma-jobi, adlay seed, Coixseed, ma-yuen

Before middle school even started, I was one of the first kids in my class whose face started to break out with lovable acne. At first, I went along with the pharmaceutical products peers would purchase – you know, the ones you find in teen magazines with fresh, photoshop-tampered faces looking as un-angsty as possible – except they didn’t have photoshop back then, and it was far from becoming the verb we use now. Luckily, my acne was primarily hidden under my bangs. But the lotions and solutions dried up my face and at times, depleted the color! Finally, my mom said enough was enough – of course, she had just heard about something new to try: Chinese pearl barley. Like with most dietary solutions, it took a few months before I suddenly noticed that much of my acne on my forehead had vanished or began to fade. Furthermore, my skin, overall, felt less dry even before applying lotions. So by the time I entered middle school, I was mostly acne-free as I watched the rest of my classmates go through the motions.

How to cook Chinese pearl barley: Chinese pearl barley can be mixed into rice and takes the same amount of time to cook. Therefore, I usually just put as much barley as half the amount of rice I use in my rice cooker. I also put pearl barley into my morning cereal mixture – see previous fox nut entry. Chinese pearl barley has also been powdered to use for tea, known as, “Job’s tears tea.”

Where to find it: Chinese pearl barley can be found in Asian grocery stores in transparent, plastic packaging, typically labeled, “Pearl barley.” It is spherical, pearl white, and larger than rice. There’s also a brownish groove on one side of the grain.

What else: Now, before getting too excited about barley’s wonderwork and going out to get a six-pack of beer or a bottle of barley wine, Chinese pearl barley is not really barley at all. While misleadingly called “barley,” it is not in the same genus as true barley (Hordeum vulgare). While barley, or H. vulgare, has its own healthy benefits, Chinese pearl barley has also been known as an anti-tumor agent and an alternative treatment for cancer. Chinese pearl barley is used as a traditional Chinese tonic for primarily the skin, lungs, and the spleen. See next section on who’s done the research.

Who’s done the research:

  • The neutral lipid isolated from the endosperm of Job’s tears (NLEJ) has been known to possess an anticancer activity with relatively low toxicity. The present study was designed to examine its antiproliferative effects in the PaTu-8988 and SW1990 human pancreatic cancer cells and to investigate its potential mechanism(s). The data show that NLEJ inhibits pancreatic cancer cell growth through induction of apoptosis and cell cycle arrest as well as regulation of gene expression in vitro. Therefore, NLEJ might be a chemotherapeutic agent against pancreatic cancer. – Bao Y, et al. Neutral lipid isolated from endosperm of Job’s tears inhibits the growth of pancreatic cancer cells via apoptosis, G2/M arrest, and regulation of gene expression. Gastroenterol Hepatol 20(7):1046-53, 2005 Jul.
  • Previous results demonstrated that the methanolic extract of adlay seed exerted an antiproliferative effect on human lung cancer cells in vitro and in vivo and might prevent tobacco carcinogen-induced lung tumorigenesis. In this study, the methanolic extract of adlay seed was tested for its regulation of COX-2 expression of human lung cancer cells. The data demonstrated that treatment of the methanolic extract reduced the PGE(2) level in serum and inhibited COX-2 expression of tumor tissues in nude mice. Taken together, the results suggest that inhibition of COX-2 is one of the mechanisms by which the methanolic extract of adlay seed inhibits cancer growth and prevents lung tumorigenesis. – Hung WC, et al. Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. J Agric Food Chem 51(25):7333-7, 2003 Dec 3.
  • This study examined the effects of different extracts of adlay seed on the growth of human lung cancer cells in vitro and in vivo. The data showed that a methanolic extract, but not a water extract, of adlay seed exerted an antiproliferative effect on A549 lung cancer cells by inducing cell cycle arrest and apoptosis. Groups of mice were pre-fed with different diets, followed by feeding with NNK-containing drinking water for 8 months. The results indicated that feeding with diet containing 30% of powdered adlay seed reduced the number of surface lung tumors by approximately 50%. Taken together, these results indicate that the components of adlay seed exert an anticancer effect in vitro and in vivo and may be useful for the prevention of lung tumorigenesis. – Chang HC, et al. Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and invivo. J Agric Food Chem 51(12):3656-60, 2003 Jun 4.
  • Five active compounds that inhibit cancer cells were isolated from adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf), and their structures and activities in vitro were characterized. These compounds showed anti-cancer activities with IC(50) values between 28.6 and 72.6mug/mL. – Lee MY, et al. Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran. Food Chem Toxicol 46(6):1933-9, 2008 Jun.
  • A pharmaceutical grade extract of Coix lachryma-jobi seeds is currently the most commonly used treatment for cancer in China. Although clinical data support the use of this preparation of a Traditional Chinese Medicine for cancer treatment, biological basis for the activity of this preparation has not been previously established. To address this issue, we first evaluated the anti-neoplastic activity of a Coix extract emulsion in xenografts of MDA-MB-231 breast cancer cells and found that the extract significantly inhibits growth of MDA-MB-231 xenografts in athymic nude mice. We determined that Coix seed extract also significantly affects gene expression in these cells, including downregulation of genes that are considered to be important in neoplasia. We concluded that this Traditional Chinese Medicine-based cancer treatment affects cellular pathways of recognized importance in neoplasia. – Woo JH, et al. Coix seed extract, a commonly used treatment for cancer in China, inhibits NFkappaB and protein kinase C signaling. Cancer Biol Ther 6(12):2005-11, 2007 Dec.
  • To find out whether the immunohistochemical expression of neuropeptid Y (NPY) and leptin receptor (LR) in the rat hypothalamus is influenced by adlay seed water extract (adlay), obesity in rats was induced by high fat diet (HFD) for 8 weeks; these rats were injected with 50 mg/100 g body weight adlay daily for 4 weeks. The results suggest that adlay may regulate neuroendocrine activity in the brain. Accordingly, administration of adlay may be considered for therapies targeting obesity. – Kim SO, et al. The water extract of adlay seed (Coix lachrymajobi var. mayuen) exhibits anti-obesity effects through neuroendocrine modulation. Am J Chin Med 35(2):297-308, 2007